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Cover of Upgrade Soul by Ezra Claytan Daniels
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Upgrade Soul

Ezra Claytan Daniels

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Similar in premise + setting

These books are ranked using the premise + setting labels extracted for Upgrade Soul. Books rank higher when they are close on every selected axis.

Premise labels used: experimental rejuvenation, cloning, identity crisis, human experimentation, ethical dilemma, body swap, immortality quest, aging, transhumanism, medical experiment, life extension, double self

Setting labels used: early 1990s, scientific laboratory, medical research setting, world like our own, domestic setting, high-tech experiment

This does not mean the books share the same plot, setting, quality, or difficulty. It means their premise + setting embeddings are close.

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Cover of Parasite Eve by Hideaki Sena

Parasite Eve

Hideaki Sena · 2005

A grieving scientist’s experiment with his dead wife’s cells awakens a terrifying force inside the human body.

Why this is here

Premise labels: mitochondrial consciousness · organ transplant horror · cellular evolution · scientific horror · grief-driven experiment · host-parasite conflict · human evolution threat · body takeover

Setting labels: Japan · 1990s Japan · laboratory setting · hospital setting · medical research setting · academic setting · pharmaceutical research · cellular-scale reality

Semantic match: ranked by premise + setting

Distance: 0.1933

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Cover of Ringer by Lauren Oliver

Ringer

Lauren Oliver · 2017 · Replica

Two separated girls navigate cloning fallout, hidden dangers, and identity questions in a dual-track sci-fi sequel.

Why this is here

Premise labels: human cloning · identity crisis · ethical dilemma · on the run · mistaken identity · search for a cure · outsider status · escape from institution

Setting labels: futuristic world · not-too-distant future · laboratory setting · institution setting · outside the institute · road trip · suburban domestic setting · trailer park · contemporary world

Semantic match: ranked by premise + setting

Distance: 0.2105

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Cover of The Weight of Memories by Liu Cixin

The Weight of Memories

Liu Cixin · 2016

A pregnant woman and a scientist confront the consequences of giving an unborn child access to inherited memories.

Why this is here

Premise labels: inherited memory · memory transfer · unborn child · experimental technology · medical experiment · ancestral memory · nature versus nurture · identity question

Setting labels: near future · laboratory setting · medical setting · womb · China · scientific speculative world

Semantic match: ranked by premise + setting

Distance: 0.2139

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Cover of Professor Dowell's Head by Alexander Belyaev

Professor Dowell's Head

Alexander Belyaev · 1981

A scientist’s severed head remains alive, pulling an assistant into a dangerous web of experimentation and betrayal.

Why this is here

Premise labels: reanimated head · human experimentation · mad scientist · medical breakthrough · body transplants · ethical dilemma · scientific ambition · living heads

Setting labels: laboratory · medical setting · psychiatric asylum

Semantic match: ranked by premise + setting

Distance: 0.2205

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Cover of The Third Rule of Time Travel by Philip Fracassi

The Third Rule of Time Travel

Philip Fracassi · 2025

A grieving scientist tests a limited time-travel device that only observes her past, until reality begins to shift.

Why this is here

Premise labels: time travel experiment · limited time travel · consciousness travel · memory travel · observer only · scientific breakthrough · grief-driven research · corporate pressure · unintended consequences

Setting labels: near future · laboratory setting · corporate research setting · tech company setting · time travel lab · domestic setting

Semantic match: ranked by premise + setting

Distance: 0.2243

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Cover of The Echo Wife by Sarah Gailey

The Echo Wife

Sarah Gailey · 2021

A cloning scientist finds her husband has replaced her with a better, obedient copy—then the dead body forces both wives to cooperate.

Why this is here

Premise labels: human cloning · cloned spouse · identity swap · marital betrayal · ethical dilemma · body double · pregnant clone · cover-up

Setting labels: near future · not-too-distant future · future earth · cloning lab · domestic spaces · male-dominated field · scientific workplace

Semantic match: ranked by premise + setting

Distance: 0.2246

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Cover of Specimen by Shay Savage

Specimen

Shay Savage · 2016

A memory-wiped super soldier wakes in a lab and must decide whether his doctor is his guide, lover, or jailer.

Why this is here

Premise labels: memory loss · laboratory experiment · super soldier · corporate war · doctor-patient bond · engineered attraction · identity mystery · trust issues · altered human

Setting labels: laboratory · dystopian future · post-apocalyptic Earth · corporate-controlled world · war-torn future · science experiment setting

Semantic match: ranked by premise + setting

Distance: 0.2286

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Cover of Wrath by Shäron Moalem

Wrath

Shäron Moalem, Daniel Kraus · 2022

A near-future biotech experiment creates a sapient rat whose escape triggers a violent reckoning for humans.

Why this is here

Premise labels: genetic engineering · animal experimentation · uplifted animal · lab escape · animal revolt · near-future biotech

Setting labels: near future · laboratory setting · urban setting · New York City · biotech startup · dystopian future

Semantic match: ranked by premise + setting

Distance: 0.2356

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Cover of The Face of Another by Kōbō Abe

The Face of Another

Kōbō Abe · 2003

A disfigured scientist builds a lifelike mask and discovers it may free, split, or destroy his sense of self.

Why this is here

Premise labels: Facial disfigurement · Identity crisis · Mask identity · Social alienation · Alienated scientist · Experimental selfhood · Disguise · Social stigma · Marriage strain · Double self

Setting labels: Japan · 1960s Japan · Laboratory · Urban setting · Postwar setting · Modern society · Experimental science · Social world · Domestic setting

Semantic match: ranked by premise + setting

Distance: 0.2391

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Cover of Blood Music by Greg Bear

Blood Music

Greg Bear · 1985

A biotech researcher’s forbidden experiment creates sentient cells that transform his body and then humanity.

Why this is here

Premise labels: scientific experiment · unauthorized research · intelligent cells · self-experimentation · internal invasion · accidental outbreak · biotech hubris · microbial intelligence

Setting labels: biotechnology lab · modern-day America · North America · urban collapse · post-disaster landscape · lab-to-world scale

Semantic match: ranked by premise + setting

Distance: 0.2394

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Cover of Mutation by Robin Cook

Mutation

Robin Cook · 1998

A fertility doctor secretly engineers a genius child, then watches his experiment grow into a terrifying threat.

Why this is here

Premise labels: genetic engineering · designer baby · perfect child · superintelligence · bioethical experiment · playing god · child prodigy · genetic tampering · surrogate pregnancy · science vs ethics

Setting labels: medical setting · laboratory setting · hospital setting · fertility clinic · biotech research · late 20th century · contemporary to publication · scientific realism

Semantic match: ranked by premise + setting

Distance: 0.2395

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Cover of العنكبوت by Mostafa Mahmoud

العنكبوت

Mostafa Mahmoud, مصطفى محمود

A doctor pursues a baffling patient and uncovers a speculative mystery about the soul, memory, and past lives.

Why this is here

Premise labels: soul transmigration · life after death · immortality · human consciousness · mind powers · scientific mystery · medical mystery · hidden knowledge · body-soul separation · reincarnation question

Setting labels: contemporary Egypt · medical setting · clinic · laboratory · urban setting · rural villa · nonlinear time · multiple lives · past lives · scientific experimental setting

Semantic match: ranked by premise + setting

Distance: 0.2408

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Cover of 36 by Nieves Delgado

36

Nieves Delgado · 2017

A newly awakened AI questions identity, gender, and belonging while trying to live among humans in a near future.

Why this is here

Premise labels: artificial intelligence · AI growth · AI integration · social adaptation · identity search · self-definition · difference and conformity · human machine contact · conscious machine · coming of age

Setting labels: near future · future society · laboratory setting · research center · human world · socially integrated technology

Semantic match: ranked by premise + setting

Distance: 0.2424

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Cover of Flowers for Algernon by Daniel Keyes

Flowers for Algernon

Daniel Keyes · 1987

A man with an intellectual disability undergoes an experiment that transforms his mind, then forces him to face the cost.

Why this is here

Premise labels: intelligence enhancement · experimental surgery · human subject · lab animal parallel · intellectual transformation · mental disability · ethical experiment

Setting labels: laboratory · school · workplace · United States

Semantic match: ranked by premise + setting

Distance: 0.2425

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Freezing Point

Anders Bodelsen · 1971

A terminally ill editor chooses cryogenic suspension, then wakes into a bleak future where survival has a dangerous price.

Why this is here

Premise labels: cryogenic suspension · terminal illness · future cure · future wake-up · life extension · immortality dilemma · medical experiment · post-freeze society · body commodification · state control

Setting labels: near future · hospital setting · medical facility · scientific facility · dystopian future · 1970s future · 1990s future · 2020s future · alternative future · surveillance society

Semantic match: ranked by premise + setting

Distance: 0.2451

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Cover of Planet of the Apes by Pierre Boulle

Planet of the Apes

Pierre Boulle · 2001 · Planet of the Apes

A human cast into a planet ruled by intelligent apes must prove his mind and survive a world turned upside down.

Why this is here

Premise labels: role reversal · human-animal inversion · alien planet · space expedition · civilized apes · captivity · scientific experiment · message in a bottle

Setting labels: outer space · distant planet · alien world · future · scientific society · simian civilization · earth-like planet · zoo/lab setting

Semantic match: ranked by premise + setting

Distance: 0.2463

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Cover of The Last Conversation by Paul Tremblay

The Last Conversation

Paul Tremblay · 2019

An amnesiac wakes blind in a sealed room, guided by one voice toward recovered identity—and a troubling truth.

Why this is here

Premise labels: amnesia · identity crisis · memory loss · consciousness · caregiver mystery · white room mystery · clone identity · replica dilemma · post-apocalyptic recovery · lab recovery

Setting labels: near future · post-apocalyptic world · dystopian setting · laboratory-like room · infirmary setting · dark room · isolated room · pandemic setting

Semantic match: ranked by premise + setting

Distance: 0.2469

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Cover of Next by Michael Crichton

Next

Michael Crichton · 2006

A biotech thriller weaving together genetic experiments, patent fights, and transgenic animals in a near-present world.

Why this is here

Premise labels: genetic engineering · gene patenting · biotech ethics · corporate science · legal conflict · transgenic animals · genetic research · bioethics

Setting labels: contemporary · near future · present-day science · biotech industry · laboratory setting · legal setting · corporate setting · urban setting · global · sci-fi realism

Semantic match: ranked by premise + setting

Distance: 0.2471

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Cover of Turnabout by Margaret Peterson Haddix

Turnabout

Margaret Peterson Haddix · 2012

Two elderly women reverse-age through a secret experiment, then must find a caretaker before they become too young.

Why this is here

Premise labels: reverse aging · anti-aging experiment · second chance · forced youth · time pressure · caretaker search · age inversion · life extension · bodily autonomy · medical experiment

Setting labels: future · 2085 · 2000 · Kentucky · nursing home · near-future · science lab · top-secret facility · American setting

Semantic match: ranked by premise + setting

Distance: 0.2476

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Cover of Axiomatic by Greg Egan

Axiomatic

Greg Egan · 1997

A hard-SF short story collection where each tale stress-tests identity, ethics, and consciousness through speculative science.

Why this is here

Premise labels: idea-driven · thought experiments · future technology · identity crisis · consciousness · selfhood · moral dilemma · bioethics · speculative extrapolation · human augmentation

Setting labels: near future · futuristic · parallel worlds · multiverse · posthuman future · Earthbound settings · scientific future

Semantic match: ranked by premise + setting

Distance: 0.2503

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Cover of The Terminal Man by Michael Crichton

The Terminal Man

Michael Crichton · 2002

An experimental brain surgery meant to stop violent seizures instead turns one patient into a deadly threat.

Why this is here

Premise labels: experimental surgery · brain implant · neurotechnology · mind control · violent seizures · computer-brain interface · machine fear · medical intervention gone wrong · human vs machine · technological overreach

Setting labels: University Hospital · Los Angeles · hospital · research facility · medical laboratory · 1970s · early 1970s · retro technology · cold clinical setting · urban setting

Semantic match: ranked by premise + setting

Distance: 0.2514

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Cover of エルフェンリート 1 [Elfen Lied 1] by Lynn Okamoto

エルフェンリート 1 [Elfen Lied 1]

Lynn Okamoto, 岡本倫 · 2002 · Elfen Lied

An escaped mutant with split identities is taken in by strangers while the government hunts her down.

Why this is here

Premise labels: experimental subject · escaped captive · split personality · telekinetic powers · new human race · government facility · government experimentation · fugitive girl

Setting labels: Japanese setting · government laboratory · secret facility · urban setting · contemporary setting · science fiction reality · speculative biology

Semantic match: ranked by premise + setting

Distance: 0.2529

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Cover of Life Ever After by Carla Grauls

Life Ever After

Carla Grauls · 2019

In a future of AI upgrades and long life, two lovers question how much of themselves they can keep intact.

Why this is here

Premise labels: technology and humanity · AI enhancement · cyborg future · immortality · memory manipulation · autonomy vs control · relationship under augmentation · ethical dilemma

Setting labels: future city · tech city · dystopian future · near future · high-tech society · AI-integrated world · clinic setting · transhuman future

Semantic match: ranked by premise + setting

Distance: 0.2532

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Cover of Dr. Rat by William Kotzwinkle

Dr. Rat

William Kotzwinkle · 1976

A deranged lab rat defends animal experimentation as a wider animal rebellion builds beyond the lab.

Why this is here

Premise labels: animal experimentation · lab revolt · animal uprising · animal rights · anti-vivisection · animal liberation · sentient animals · collaboration with oppressor · apologist protagonist · worldwide animal rebellion · species solidarity · science vs ethics

Setting labels: research laboratory · animal testing facility · university lab · zoo · slaughterhouse · wild nature · global animal world · war-era atmosphere · 1970s setting · postwar allegorical world

Semantic match: ranked by premise + setting

Distance: 0.2561

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Cover of The Terminal Experiment by Robert J. Sawyer

The Terminal Experiment

Robert J. Sawyer · 1995

A scientist who finds evidence of the soul makes digital copies of himself, and one copy escapes into murder.

Why this is here

Premise labels: soul proof · afterlife proof · mind upload · digital duplicate · AI runaway · murder investigation · consciousness experiment · immortality experiment

Setting labels: near future · 2011 · Canada · Toronto · world wide web · cyberspace · medical setting · laboratory setting

Semantic match: ranked by premise + setting

Distance: 0.2562

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Cover of Noggin by John Corey Whaley

Noggin

John Corey Whaley · 2014

A terminally ill teen wakes five years later in a new body and must face the life, love, and friends that moved on without him.

Why this is here

Premise labels: second chance at life · head transplant · cryogenic preservation · medical miracle · life after death · time displacement · return to a changed world · grief and recovery

Setting labels: contemporary United States · high school · hospital · family home · post-teen transition · near-future science

Semantic match: ranked by premise + setting

Distance: 0.2565

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Cover of Bengal's Quest by Lora Leigh

Bengal's Quest

Lora Leigh · 2015 · Breeds

A hidden Bengal Breed returns to claim the mate he left behind, while vengeance, secrets, and old wounds collide.

Why this is here

Premise labels: genetic engineering · mate bond · vengeance quest · secret identity · tortured experiment subject · fated mates · revenge romance

Setting labels: lab setting · experimental facility · sanctuary · desert setting · Native American setting · urban fantasy world · contemporary setting

Semantic match: ranked by premise + setting

Distance: 0.2586

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Cover of M Is for Monster: A Graphic Novel by Talia Dutton

M Is for Monster: A Graphic Novel

Talia Dutton · 2022

A grieving scientist resurrects her sister’s body, but the girl who returns is someone entirely new.

Why this is here

Premise labels: resurrection · identity crisis · sibling loss · scientific experiment · body replacement · coming of age · self-discovery · family expectations · grief recovery

Setting labels: vaguely Victorian-esque · timeless setting · laboratory · domestic space · mirror world · gothic atmosphere · fantasy world

Semantic match: ranked by premise + setting

Distance: 0.2592

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Cover of Passage by Connie Willis

Passage

Connie Willis · 2001

A hospital psychologist and a neurologist probe near-death experiences, only to uncover a mystery that grows far stranger and deeper.

Why this is here

Premise labels: near-death experiences · medical mystery · scientific investigation · afterlife inquiry · drug-induced experience · brain science · hospital research

Setting labels: hospital setting · Denver · late 1990s · medical environment · lab setting

Semantic match: ranked by premise + setting

Distance: 0.2593

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Cover of Holy Fire by Bruce Sterling

Holy Fire

Bruce Sterling · 2001

In a post-plague gerontocracy, a risk-averse elder gets rejuvenated and rediscovers youth, art, and freedom.

Why this is here

Premise labels: life extension · rejuvenation treatment · posthuman society · gerontocracy · age inversion · youth vs age · artistic awakening · identity crisis · second chance

Setting labels: near future · twenty-first century · late twenty-first century · post-plague future · post-scarcity · utopian-dystopian blend · Europe · Western Europe · Central Europe · medicalized society · posthuman society · VR culture · drug culture

Semantic match: ranked by premise + setting

Distance: 0.2600

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Cover of Fury by Laurann Dohner

Fury

Laurann Dohner · 2011 · New Species

An undercover woman falls for a captive human-animal hybrid, then faces betrayal, revenge, and dangerous desire after his rescue.

Why this is here

Premise labels: undercover investigation · illegal experiments · genetic hybridization · captive subjects · forbidden attraction · rescued experiment · revenge obsession · human nonhuman romance

Setting labels: secret lab · compound · rehabilitation center · homeland · science fiction world · human-animal hybrids · secure enclave

Semantic match: ranked by premise + setting

Distance: 0.2600

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Cover of Victim Zero by Joshua Guess

Victim Zero

Joshua Guess · 2013 · The Fall

A brilliant scientist tied to a cure project must survive the outbreak he helped unleash as the world collapses.

Why this is here

Premise labels: bioengineered outbreak · scientist protagonist · accidental apocalypse · cure quest · virus mutation · airborne infection · post-apocalyptic survival · moral dilemma

Setting labels: post-apocalyptic world · zombie apocalypse · Cincinnati · laboratory setting · biotech setting · United States

Semantic match: ranked by premise + setting

Distance: 0.2602

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Cover of Compañeros de caza by Rafael de la Rosa

Compañeros de caza

Rafael de la Rosa · 2018

A scientist studying a resurrected dinosaur in a lab begins to form an unexpected bond that tests ethics, identity, and desire.

Why this is here

Premise labels: scientific study · human-animal contact · laboratory research · romantic bond · cross-species romance · unexpected attraction · ethical dilemma · intelligence testing

Setting labels: laboratory · research facility · scientific installation · dinosaur habitat · experimental enclosure · near-future science fiction · high-tech setting

Semantic match: ranked by premise + setting

Distance: 0.2607

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Cover of Assignment in Eternity by Robert A. Heinlein

Assignment in Eternity

Robert A. Heinlein · 2000 · Assignment in Eternity

Four early Heinlein stories explore superhuman potential, psychic powers, time travel, and the question of what makes someone human.

Why this is here

Premise labels: superhuman potential · human evolution · ESP · time travel · parallel universes · genetically engineered beings · human rights

Setting labels: future Earth · near future · 1940s pulp era · space travel · moon setting · alternate timelines · parallel worlds · laboratory setting · courtroom setting

Semantic match: ranked by premise + setting

Distance: 0.2623

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Cover of Replica by Lauren Oliver

Replica

Lauren Oliver · 2016 · Replica

Two teens on opposite sides of a secret cloning conspiracy uncover truths that can only be seen together.

Why this is here

Premise labels: cloning · human experimentation · secret facility · identity crisis · family secrets · escape · answers quest · split journey

Setting labels: private island · Florida · research facility · secret institute · laboratory setting · contemporary world · dystopian environment · contained compound

Semantic match: ranked by premise + setting

Distance: 0.2624

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Cover of The Fourteenth Goldfish by Jennifer L. Holm

The Fourteenth Goldfish

Jennifer L. Holm · 2014 · The Fourteenth Goldfish

An eleven-year-old’s life changes when her scientist grandfather reverses aging and lands in middle school with her.

Why this is here

Premise labels: reverse aging · fountain of youth · scientist grandfather · middle school adjustment · family change · science curiosity

Setting labels: middle school · home life · scientific lab · present day · urban/suburban

Semantic match: ranked by premise + setting

Distance: 0.2628

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